Selective Serotonin Reuptake Accelerators (SSRAs)

What are Selective Serotonin Reuptake Accelerators (SSRAs)?

Selective Serotonin Reuptake Accelerators (SSRAs) are a new class of antidepressants. SSRAs appear to be very effective in treating depression while causing few few side effects.

How Selective Serotonin Reuptake Accelerators (SSRAs) Work

SSRAs are the opposite of SSRIs (selective serotonin reuptake inhibitors). SSRAs actually increase the reuptake of Serotonin and decreasing concentrations. Why this mechanism of action decreases depression is not clear, but studies have shown SSRAs such as Stablon (Tianeptine) to be effective antidepressants.

SSRIs are described as 'selective' because they affect only the reuptake pumps responsible for serotonin. Earlier antidepressants also affect other monoamine neurotransmitters. As a result, SSRIs lack some of the side effects of the the more general drugs.

Examples of Selective Serotonin Reuptake Accelerators (SSRAs)

The only Selective Serotonin Reuptake Acclerator (SSRA) currently available is Tianeptine, marketed under the brand name of Stablon.

Side effects of Selective Serotonin Reuptake Accelerators (SSRAs)

Possible side effects of Selective Serotonin Reuptake Accelerators (SSRAs) that have been reported include:

• as dry mouth
• anorexia
• nausea
• flatulence
• gastralgia

In rare cases were the drug has been administered in the late evening, insomnia and nightmares have been reported. Further rare side effects include dizziness, faintness and respiratory discomfort. The side effects of SSRAs appear to be few compared to many other antidepressants.

Important Information About Selective Serotonin Reuptake Accelerators (SSRAs)

SSRAs should not be taken with monoamine oxidase inhibitors (MAOIs). There must be an interval of at least fifteen days between MAOI and SSRA use. Use of SSRAs with other anti-depressants, especially those that alter serotonin levels should only be undertaken under the close supervision of your physician.